High adherence to prophylactic treatment not only reduces the number of spontaneous bleeding episodes in patients with hemophilia A, but it also improves their physical activity, according to a study.
The study, “Physical activity improved by adherence to prophylaxis in an Italian population of children, adolescents and adults with severe haemophilia A: the SHAPE Study,” was published in Blood Transfusion.
Hemophilia is a genetic blood disorder that affects the body’s ability to form blood clots to prevent excessive bleeding. In hemophilia A, this inability of the blood to clot is caused by the lack of a specific clotting protein, called factor VIII (FVIII).
Current treatments for hemophilia A are based on providing the missing FVIII to patients as a prophylaxis, or preventive measure, to avoid spontaneous bleeding episodes and other complications of the condition, such as arthropathy (joint disease).
“However, the prophylaxis regimen is not without problems. The main challenges are related to the cost of this therapy for national health systems and the burden of frequent intravenous infusions. [Nevertheless,] adherence to the prescribed prophylactic regimen is crucial to treatment efficacy,” the investigators wrote.
Learn more:
Hemophilia Prophylaxis Adherence
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The study, “Physical activity improved by adherence to prophylaxis in an Italian population of children, adolescents and adults with severe haemophilia A: the SHAPE Study,” was published in Blood Transfusion.
Hemophilia is a genetic blood disorder that affects the body’s ability to form blood clots to prevent excessive bleeding. In hemophilia A, this inability of the blood to clot is caused by the lack of a specific clotting protein, called factor VIII (FVIII).
Current treatments for hemophilia A are based on providing the missing FVIII to patients as a prophylaxis, or preventive measure, to avoid spontaneous bleeding episodes and other complications of the condition, such as arthropathy (joint disease).
“However, the prophylaxis regimen is not without problems. The main challenges are related to the cost of this therapy for national health systems and the burden of frequent intravenous infusions. [Nevertheless,] adherence to the prescribed prophylactic regimen is crucial to treatment efficacy,” the investigators wrote.
Learn more:
Hemophilia Prophylaxis Adherence